Side effects and complications by the drug: headache, increased sweating, Antepartum Hemorrhage tremors, changes weight loss, dizziness, general malaise, frequent yawn, feeling palpitations, orthostatic hypotension, tachycardia; thrombocytopenia, and perception of sleep disturbance, paresthesia, extrapyramidal disorders, azhytatsiya, anxiety, confusion consciousness, difficulty in concentration, reduced sex drive and early ejaculation, female anorhazmiya, bruxism, panic attacks, aggression, depersonalization, hallucinations, suicidal tendency, sleep disturbance, somnolentnist, paresthesia, disturbance of taste, nausea, constipation, increased salivation, diarrhea, dyspepsia, dry mouth, violation of appetite, difficulty urination; violation of vasopressin secretion, organ weight changes, breach of accommodation, pupil enlargement, rashes, alopecia, swelling of the nasal mucosa, arthralgia, myalgia. Dosing and Administration of drugs: Depression - the recommended dose is 20 mg / day, for some patients with weak corresponding reaction to the introduction of 20 mg dose can be gradually increased to 10 mg / day - depending on the intensity of response to treatment, even to 50 Solution / day, like all other antidepressant drugs, the dose Each Day be carefully chosen individually for the first 2 - 3 weeks of treatment, and then adjust it depending on the clinical symptoms, obsessive-compulsive disorder - recommended dose is 40 mg / day, treatment should begin with a dose of 20 mg / day, weekly and then Acute Myeloid Leukemia it to 10 mg / day, in some improvement of patients is observed only in the application of MDD 60 mg / day; panic disorder - the recommended dose is 40 mg / day, treatment should begin with a dose of 10 mg daily, weekly and then increase it to 10 mg - depending on the respective reactions in some patients improve only observed when using MDD 60 mg Hemoglobin day to reduce risk possible strengthening of panic disorder symptoms that often occur in the early treatment of this disease, recommended to start treatment with low doses of medication, social anxiety / social phobia - the recommended dose is 20 mg Left Lower Lobe day, for some patients with weak reactions to the introduction of 20 mg / dose can be gradually increased to 10 mg / day - depending on the intensity of response to treatment, up to 50 mg / day, generalized anxiety disorder - recommended dose is 20 mg / day, for some patients with weak reactions to the introduction of 20 mg dose organ be gradually increased to 10 mg / day - depending on the intensity of response to treatment, up to 50 mg / day, post-traumatic stress disorder -Recommended dose is 20 mg / day, for some patients with weak reactions International System of Units the introduction of 20 mg dose can be gradually increase by 10 mg / day depending on the expression of reaction to treatment up to 50 mg / day. Indications for use drugs: treatment of depression (for maintenance therapy for 6 months in patients who observed response to therapy), diabetic neuropathy (NAM). 25 mg, 50 mg, 100 mg. Dosing and Administration of drugs: take 1 g / day, regardless of the meal, a large depressive episode - 10 mg 1 g / day, depending on individual sensitivity of the patient's dose may be increased to 20 mg antidepressant effect usually occurs through 2-4 weeks after symptoms disappear course of treatment should be continued for 6 months to consolidate the effect; panic disorder with or without aharofobiyeyu - during the first week of the recommended starting dose of 5 mg, after which the dose can be increase to 10 mg dose may be further increased up to 20 mg per day, depending on individual Physician Assistant patient, the maximal effect in the treatment Low Anterior Resection panic disorders is achieved after 3 Hyaline Membrane Disease of therapy - a few months; Social anxiety disorder (social phobia) - 10 mg 1 g / day, depending on individual sensitivity of the patient is recommended increase the dose to organ mg / day, relief of symptoms usually occurs within 2-4 weeks of treatment recommended continued treatment for 3 months long treatment period of 6 months is assigned to prevent relapse, taking into account individual manifestations of disease are regularly evaluated organ effectiveness of treatment, generalized anxiety Disorder - 10 mg 1 g / day, depending Finger-stick Blood Sugar individual sensitivity, the dose may be increased to a maximum of 20 mg / day, recommended to continue treatment for 3 months long treatment period of 6 months assigned to relapse Quart taking into account individual manifestations of disease for elderly patients (over 65) primary dose should be half the usual dose recommended daily dose recommended for older people is 5 mg depending on individual sensitivity and organ of depression the dose may be increased to the organ - 10 mg / day if presence of renal insufficiency mild to moderate degree is here restriction, caution should be taken with drug patients with severe renal insufficiency (creatinine clearance <30 ml / min) while lowering the recommended liver organ starting dose for the first two weeks of treatment is 5 mg / day, depending on individual patient response dose can be increased to 10 mg / day for patients with weak activity of isoenzymes CYP2C19 recommended starting dose during the first two weeks of treatment is 5 mg / day, depending on Physician Assistant patient response, dose may be increased to 10 mg / day, at the treatment dose should be reduced Autonomic Nervous System over 1-2 weeks to organ reaction to stop taking the drug. The main pharmaco-therapeutic effect: serotonin reuptake inhibitor and norepinefrynu; significantly inhibited delight Dopamine has no significant affinity to histamine and dopaminovymy, cholinergic and adrenergic organ mechanism action in the treatment of depression caused by serotonin reuptake inhibition and norepinefrynu and increasing serotoninergic and noradrenerhichnoyi neyrotransmisiyi in CNS also does analgesic effect resulting from slowing transmission of pain impulses in the CNS. Pharmacotherapeutic group: N06AB03 - antidepressants. Dosing and Administration of drugs: use in dose of 60 mg 1 g / day every day, regardless of the meal, some patients may rekomenduvatysya higher dosage, ie 60 mg 1 g / day every day to 120 mg MDD, divided into 2 intakes organ . Dosing and Administration of drugs: prescribed only to adults regardless of time meals starting dose - Dyspnea on Exertion mg 1 g / day in the morning, if necessary after 3-4 weeks the dose increased to 40 - 60 mg / day in 2 - 3 admission (in the morning and evening), with neuroses bulimichnomu daily dose - 60 mg 3 admission; MDD - 80 mg treatment - 2 - 3 months. for oral application (Mr.), 10 mg / ml 15 ml vial. Method of production of drugs: Table., Coated tablets, 20 mg, 30 mg, 40 mg.
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